[The value of T-cell receptor gene rearrangement in the auxiliary diagnosis of T-cell large granular lymphocytic leukemia].
Abstract
The detection rate of TCR gene rearrangement for T-cell clones is higher than that of TCRVβ and TRBC1. Patients with positive TCRβ (D-J) gene rearrangement have a higher incidence of B symptoms, lower incidence of autoimmune diseases, and lower HGB levels. Patients with positive TCRγ gene rearrangement are more likely to develop STAT3 gene mutation. These characteristics may be helpful in the differential diagnosis of T-LGLL.
Fields of Study & Subjects
T-cell and B-cell Immunology
Lymphoma Diagnosis and Treatment
Acute Myeloid Leukemia Research
Publication details
- Journal / source
- PubMed
- Volume
- 47
- Issue
- 1
- Pages
- 42–49
- Publication date
- 14 January 2026
- Language
- ZH