[Clinical characteristics and prognosis of myelodysplastic neoplasms with chromosome 1 abnormalities].

PubMed 2026 Open access

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Authors: Z L Kuang, B Li, T J Qin, Z F Xu, S Q Qu, C W Li, L J Pan, Q Y Gao, M Jiao, Y J Ja, Q Sun, Zhijian Xiao
DOI: 10.3760/cma.j.cn121090-20250820-00393
Cited by: 0

Abstract

Among MDS patients with chromosome 1 abnormalities, 1q trisomy is associated with lower blast counts and reduced TP53 mutation rates/VAF, correlating with significantly improved OS. IB and SF3B1 mutations independently predict poorer survival outcomes in this patient population.

Fields of Study & Subjects

Acute Myeloid Leukemia Research Retinoids in leukemia and cellular processes Hematopoietic Stem Cell Transplantation

Publication details

Journal / source
PubMed
Volume
47
Issue
1
Pages
27–33
Publication date
14 January 2026
Language
ZH