Topical and Systemic Retinoids in the Geriatric Population

Retinoids are defined as molecules that activate cellular proliferation and differentiation by binding to retinoic acid receptors. Since they are not produced in the body, they need to be obtained externally through food. Retinoids have natural and synthetic forms. Topical and systemic retinoids are used in the treatment of many diseases in geriatric dermatology. In the literature, there are limited studies and data regarding the use, efficacy, and side effects of retinoids in the geriatric population over the age of 65. It has been reported that topical retinoic acids may cause more irritation in patients aged 65 and above. Due to lower tolerance in the geriatric population, it is suggested that systemic retinoids should be started and used at lower doses compared to younger individuals. Although there is no specific dose recommendation for systemic retinoids in the geriatric population, data on their use, efficacy, and side effects are limited. Whether the treatment response differs from that of younger patients is not fully known. When adjusting the dose for patients, the reduced hepatic, renal, and cardiac functions in the geriatric population should be considered, and the lowest possible doses should be used.