Methotrexate

Methotrexate is an immunosuppressive drug used successfully in many dermatological indications. Patients in the geriatric population, may be more sensitive to significant side effects of methotrexate, such as hepatotoxicity, pancytopenia, renal and pulmonary toxicity, due to age-related decreases in albumin concentration and renal and liver functions. In addition to age-related physiological changes, risks such as comorbidities, multiple drug use, and drug misuse due to decreased cognitive functions require careful use of methotrexate. Routine monitoring of laboratory parameters and folic acid supplementation are recommended to ensure the safety and tolerability of methotrexate use in elderly patients.