Screwing the helical chirality through terminal peri -functionalization
Abstract
Helical chirality is an important, but underrated form of chirality than other types of chirality. Molecules with helical chirality impart a crucial role in several biological phenomena as well as in modern materials applications. Classically, the generation of chiral helicity in organic molecules relies on a ring extension by means of cycloaddition and related reactions. Recently, the peri -functionalization approach paved a new pathway for the generation of chiral helical molecules. In this article, we highlight the key advancements in these parallel approaches for the generation of helical chiral architectures.
Fields of Study & Subjects
Synthesis and Properties of Aromatic Compounds
Axial and Atropisomeric Chirality Synthesis
Supramolecular Self-Assembly in Materials
Publication details
- Journal / source
- Beilstein Journal of Organic Chemistry
- Publisher
- Beilstein Institut
- Volume
- 22
- Pages
- 205–212
- Publication date
- 28 January 2026
- Language
- EN