Design, synthesis and biological evaluation of 2,5-diaryloxazolo[4,5- d ]pyrimidin-7-ylamines as selective cytotoxic agents against HeLa cells
Abstract
Nine novel functionalized 2,5-diaryloxazolo[4,5- d ]pyrimidin-7-ylamines were designed, synthesized and characterized using 1 H, 13 C NMR, IR spectroscopy, elemental analysis, and liquid chromatography–mass spectrometry . Their anticancer activity was assessed against human cancer cell as well as non-cancer cell lines. Three compounds, 1 , 3 , and 9 , were the most cytotoxic to HeLa cells (IC 50 = 6.13 ± 1.95, 13.99 ± 1.80 and 49.92 ± 3.98 μM, respectively). However, only compounds 1 , 7 , and 9 were selective against the tested lines. Compound 9 can be classified as the most attractive and promising candidate for further development against cervical adenocarcinoma.
Fields of Study & Subjects
Synthesis and biological activity
Multicomponent Synthesis of Heterocycles
Synthesis and bioactivity of alkaloids
Publication details
- Journal / source
- Beilstein Journal of Organic Chemistry
- Publisher
- Beilstein Institut
- Volume
- 22
- Pages
- 390–398
- Publication date
- 3 March 2026
- Language
- EN