Asymmetric Mannich reaction of aromatic imines with malonates in the presence of multifunctional catalysts
Abstract
Various multifunctional enantiomerically pure organocatalysts were synthesized and screened in asymmetric Mannich reaction. Aromatic imines gave Mannich adducts with malonates in the presence of amino acid derived catalyst in very high enantiomeric purities (ee up to 98%). It is proposed that the network of hydrogen and halogen bonds with Lewis bases, together with the steric effect of the tert -butyl group of the catalyst, is responsible for the high stereoselectivity of the reaction.
Fields of Study & Subjects
Asymmetric Synthesis and Catalysis
Asymmetric Hydrogenation and Catalysis
Axial and Atropisomeric Chirality Synthesis
Publication details
- Journal / source
- Beilstein Journal of Organic Chemistry
- Volume
- 22
- Pages
- 151–157
- Publication date
- 16 January 2026
- Language
- EN