Effect of RAS Pathway Gene Mutations on Survival in Myelodysplastic Syndrome

Quality assessment / Risk of bias analysis Methodological Standards for Epidemiological Research (MASTER) scale. Strategy of data synthesisThe association between various mutations and clinical outcomes (OS, LFS and leukemia transformation) was investigated and summarized as HRs and their corresponding 95% confidence intervals (CIs), comparing outcomes between patients with and without the mutations.A random-effects metaanalysis was performed using the restricted maximum likelihood (REML) method to estimate the between-study variance.P-values less than 0.05 were considered statistically significant.Statistical analysis was conducted using Stata version 17. Subgroup analysis None. Sensitivity analysis None.