Prevalence of Chronic Traumatic Encephalopathy (CTE) in Individuals Without Repetitive Head Impact: A Systematic Review and Meta-Analysis

Rationale Current understanding of CTE prevalence is heavily influenced by selection bias i n h e re n t i n b r a i n b a n k re s e a rc h , w h e re symptomatic individuals or their families are more likely to pursue organ donation.This bias has led to high reported prevalence rates within RHIexposed groups, yet the field lacks a baseline for CTE in the general, non-exposed population.Without establishing the baseline prevalence of CTE pathology, it is difficult to accurately quantify the specific risk increase attributable to repetitive impacts versus singular traumatic brain injuries or other etiologies.By defining a baseline prevalence