Predictors of 10-Year Survival After Transcatheter Aortic Valve Replacement with First-Generation Aortic Valve: Insights from A Single Center Initial Experience

Aim: This study aimed to identify predictors of 10-year survival in patients undergoing early Transcatheter Aortic Valve Replacement (TAVR) with the first-generation CoreValve system, providing insights from a pioneering single-center experience in Turkey.Material and Methods: We retrospectively analyzed high-risk patients who underwent TAVR between April 2012 and March 2013. Baseline clinical characteristics and echocardiographic parameters were compared between survivors and non-survivors over a 10-year follow-up period. Survival analysis was performed using Kaplan-Meier curves, and Cox regression models were utilized to identify independent predictors of survival.Results: The cohort included patients with a mean age of 77.1 ± 7.7 years. The Kaplan–Meier analysis estimated the median survival time at 62 months (95% CI: 33–127), with a mean survival time of 71.6 months (95% CI: 43.9–99.3). Survivors exhibited significantly lower left ventricular (LV) end-diastolic diameter, LV mass index, and LV diastolic-systolic diameter difference compared to non-survivors. In univariate analysis, STS score, pulmonary artery pressure (PAP), LV hypertrophy pattern, LV diameter difference, and LV mass index emerged as potential predictors of long-term survival. STS score and LV diameter difference were independent predictors.Conclusion: In this study, both STS score and LV diastolic-systolic diameter difference were identified as independent predictors of 10-year survival following TAVR. These findings emphasize the critical role of precise patient evaluation and underscore the potential value of personalized procedural strategies to optimize long-term outcomes in TAVR patients