Investigation of the Relationship Between Neurogenesis and Metabolic Parameters in the Streptozotocin-Induced Alzheimer’s Disease Model

Aim: In this study, we aimed to analyze the interactions between neuroplasticity-related proteins (DCX, EGR1, sFRP3) and metabolic markers (insulin, HbA1c, asprosin) in an STZ-induced Alzheimer's disease model, as well as to evaluate how changes in these parameters affect the pathophysiology of Alzheimer's disease (AD).Material and Methods: 14 male Wistar albino rats, aged 8 to 10 weeks, weighing 250–300 g, were used. The animals were divided into two groups: control and Alzheimer's model. The AD model was created by stereotaxic injection of STZ, and the control group was injected with artificial CSF. The animals were monitored for 14 days after surgery. At the end of the study, serum samples were collected and DCX, EGR1, sFRP3, insulin, gHbA1c, and asprosin levels were analyzed by ELISA. The variables were compared between the groups, and P-values < 0.05 were considered significant.Results: DCX and EGR1 levels showed borderline changes without statistical significance (p = 0.056 and p = 0.080, respectively), while sFRP3 levels were significantly higher in the AD group (p = 0.012). Insulin levels did not differ (p = 0.829), but asprosin and gHbA1c levels were significantly higher (p = 0.046 and p = 0.000, respectively), indicating metabolic derangement. Correlation analysis showed strong positive correlations between asprosin and gHbA1c (r = 0.807, p < 0.01) and sFRP3 and EGR1 (r = 0.780, p < 0.01), suggesting interconnected roles in AD pathophysiology.Conclusion: This study shows the relationship between neurogenesis and metabolic parameters in AD.