Combined ER/PR co-positivity enhances prognostic stratification within molecular subtypes of endometrial cancer
Abstract
OBJECTIVE: To explore the prognostic value of combined estrogen receptor (ER)/progesterone receptor (PR) expression patterns within molecular subtypes of endometrial cancer (EC), particularly in the prognostically heterogeneous no specific molecular profile (NSMP) subtype. METHODS: A retrospective cohort study of 388 EC patients underwent next-generation sequencing-based molecular classification and ER/PR immunohistochemistry. ER/PR status was categorized as co-positive (coP), co-negative, or discordant. Multivariable Cox models and concordance index (C-index) analyses assessed disease-specific survival (DSS) and progression-free survival (PFS). RESULTS: ER/PR co-positivity independently predicted improved DSS overall (hazard ratio [HR]=0.143; 95% confidence interval [CI]=0.065, 0.314; p
Fields of Study & Subjects
Endometrial and Cervical Cancer Treatments
Estrogen and related hormone effects
Angiogenesis and VEGF in Cancer
Publication details
- Journal / source
- Journal of Gynecologic Oncology
- Publisher
- XMLink
- Volume
- 37
- Issue
- 4
- Pages
- e61–e61
- Publication date
- 1 January 2026
- Language
- EN