Psoriatic arthritis and pregnancy: maternal and neonatal outcomes in a clinical cohort

Aims: To evaluate obstetric and neonatal outcomes in women with psoriatic arthritis (PsA) by comparing pregnancies before and after diagnosis, as well as with healthy controls, with a focus on disease activity, treatment exposure, and flares Methods: This retrospective cross-sectional study included 227 pregnancies from 85 women with PsA and 100 pregnancies from 46 healthy controls. Maternal and neonatal outcomes were assessed, including preeclampsia, gestational hypertension, gestational diabetes, cesarean delivery, preterm birth, small for gestational age (SGA), congenital anomalies, and neonatal intensive care unit (NICU) admissions. Disease activity and flares during pregnancy were recorded. Logistic regression analyses were performed to identify predictors of composite adverse maternal and neonatal outcomes. Results: Among PsA pregnancies, 161 (71%) occurred before and 66 (29%) after diagnosis. Maternal age at conception was higher post-diagnosis, and these pregnancies showed increased rates of cesarean delivery (60.4% vs. 16.9% and 14.5%, p