Orcinol glucoside ameliorates pulmonary fibrosis by suppressing hyaluronic acid synthesis and macrophage M2 polarization via targeting hyaluronic acid synthase 2

International Journal of Molecular Medicine 2026 Open access

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Authors: Caizi Li, Xinglinzi Tang, Xiaoru Luo, Xin Lai, Jie Yang, Zheng Xu, Gulizeba Muhetaer, Yizi Xie, Xiufang Huang, Hang Li
DOI: 10.3892/ijmm.2026.5764
Cited by: 0

Abstract

, OG reduced collagen deposition, HA, and TGF‑β1 levels in BLM‑induced fibrotic mice. These findings established HAS2 as a central pathogenic factor in IPF and suggested OG as a promising therapeutic candidate, providing a novel approach for IPF treatment by targeting HA synthesis and macrophage polarization.

Fields of Study & Subjects

Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis Proteoglycans and glycosaminoglycans research Cardiac Fibrosis and Remodeling

Publication details

Journal / source
International Journal of Molecular Medicine
Volume
57
Issue
4
Pages
1–17
Publication date
10 February 2026
Language
EN