miRNA‑378a‑5p attenuates the development of abdominal aortic aneurysm via ABLIM1‑MKL1 signaling pathways

International Journal of Molecular Medicine 2026 Open access

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Authors: Jing Wang, Yujia Zou, Y S Wang, Zheming Yang, Daoshen Liu, Xiaolin Su, Haixu Song, K Xu, Chenghui Yan, Dan Liu, Y L Han
DOI: 10.3892/ijmm.2026.5768
Cited by: 0

Abstract

, miR‑378a‑5p overexpression significantly promoted the contraction ability and suppressed the migration of VSMCs, whereas miR‑378a‑5p knockdown inhibited the contraction ability and increased the migration of VSMCs. Mechanistically, it was identified that miR‑378a‑5p played a protective role in AAA development by regulating actin‑binding LIM protein 1 (ABLIM1)‑megakaryoblastic leukemia 1 (MKL1) pathway. miR‑378a‑5p exerts protective effects against AAA by maintaining VSMCs homeostasis via the ABLIM1‑MKL1 pathway. Therefore, targeting miR‑378a‑5p may be an attractive therapeutic strategy for AAA treatment.

Fields of Study & Subjects

Aortic aneurysm repair treatments MicroRNA in disease regulation Connective tissue disorders research

Publication details

Journal / source
International Journal of Molecular Medicine
Volume
57
Issue
4
Pages
1–20
Publication date
16 February 2026
Language
EN