Endothelial UNC5B regulates blood‑retinal barrier homeostasis

International Journal of Molecular Medicine 2026 Open access

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Authors: Yongfang Yao, Suyu Wang, Jiajun Li, Qianzi Jin, Z.-Q. Chen, Qin Jiang, Keran Li
DOI: 10.3892/ijmm.2026.5771
Cited by: 2
References: 72

Abstract

retinal imaging. Mechanistically, transcriptomic and protein analyses revealed that UNC5B downregulation was associated with increased extracellular matrix protein deposition and reduced Hippo pathway activity. Collectively, these findings established UNC5B as a key mediator of BRB and NVU stability, and highlighted its therapeutic potential in maintaining vascular integrity and protecting neural elements in retinal vascular diseases.

Fields of Study & Subjects

Axon Guidance and Neuronal Signaling Angiogenesis and VEGF in Cancer Barrier Structure and Function Studies

Publication details

Journal / source
International Journal of Molecular Medicine
Publisher
Spandidos Publications
Volume
57
Issue
4
Pages
1–21
Publication date
20 February 2026
Language
EN