HELLS inhibits autophagy‑dependent ferroptosis in nasopharyngeal carcinoma by modulating the Nrf2/HO‑1/GPX4 pathway

International Journal of Molecular Medicine 2026 Open access

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Authors: Chengxun Jin, Jinqiu Li, Siqi Han, Chaoluomeng Bai, JZ Yang, Zonggui Wang
DOI: 10.3892/ijmm.2026.5788
Cited by: 3
References: 55

Abstract

experiments, HELLS expression reduction inhibited tumor growth and the expression of Nrf2, HO‑1 and GPX4 while promoting autophagy. In conclusion, HELLS activates the Nrf2/HO‑1/GPX4 pathway, which inhibits autophagy‑dependent ferroptosis in NPC cells, thereby promoting NPC progression.

Fields of Study & Subjects

Ferroptosis and cancer prognosis Cancer-related molecular mechanisms research Genomics phytochemicals and oxidative stress

Publication details

Journal / source
International Journal of Molecular Medicine
Publisher
Spandidos Publications
Volume
57
Issue
5
Pages
1–15
Publication date
9 March 2026
Language
EN