Ligustroflavone protects against acute kidney injury by inhibiting ferroptosis via acting on GSK3β/NRF2 signaling

International Journal of Molecular Medicine 2026 Open access

Read full text
Authors: Jiayu Song, Long Wang, Yaru Wang, Jie Meng, Jingyi Sheng, Yongfeng Zhao, San Yan Xu, Juan Lei, Fangfang Cai, Y F Yang
DOI: 10.3892/ijmm.2026.5841
Cited by: 1
References: 54

Abstract

, LIG treatment markedly ameliorated CDDP‑induced lipid peroxidation and ferroptosis in cultured TKPTs via GSK3β inhibition and NRF2 activation. Furthermore, knockout of GSK3β also protected against CDDP‑induced cell death and LIG exerted no additional protective effects in GSK3β‑knockout TKPTs. Together, the present findings offer a new potential strategy for AKI therapies by targeting ferroptosis.

Fields of Study & Subjects

Ferroptosis and cancer prognosis Clusterin in disease pathology Cancer Mechanisms and Therapy

Publication details

Journal / source
International Journal of Molecular Medicine
Publisher
Spandidos Publications
Volume
58
Issue
1
Pages
1–15
Publication date
30 April 2026
Language
EN