Oxygen‑sensing histone demethylase KDM6A modulates chondrocyte‑to‑osteoblast transdifferentiation by activating the Wnt/β‑catenin pathway

International Journal of Molecular Medicine 2026 Open access

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Authors: Yi Rong, Hao Yu, Heng Yin, Shaoshuo Li, Yi-Xiang Wang, Zhongyuan Shen, Xinxin Ding, Fanchen Bu, Tianyi Dai, Ge’an Wu, Zhen Hua
DOI: 10.3892/ijmm.2026.5874
Cited by: 1
References: 59

Abstract

, KDM6A‑knockout mice exhibited osteogenic defects and delayed fracture healing compared with control mice. KDM6A serves as a pivotal oxygen sensor that drives CH‑to‑osteoblast transdifferentiation and enhances fracture healing through Wnt/β‑catenin pathway activation. The KDM6A‑mediated oxygen response mechanism is a potential target for enhancing bone regeneration during fracture repair.

Fields of Study & Subjects

Osteoarthritis Treatment and Mechanisms Mesenchymal stem cell research Proteoglycans and glycosaminoglycans research

Publication details

Journal / source
International Journal of Molecular Medicine
Publisher
Spandidos Publications
Volume
58
Issue
2
Pages
1–19
Publication date
28 May 2026
Language
EN