Microbiota‑derived indole‑3‑propionic acid reprograms bone marrow stem cell fate via PPARγ suppression to rescue osteoporosis

International Journal of Molecular Medicine 2026 Open access

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Authors: Jinwu Bai, Ruideng Wang, Jixing Fan, Shilong Su, Gao Si, Qinyong You, Ao Sun, Daole Hu, Shan Gao, Yang Lv, Fang Zhou
DOI: 10.3892/ijmm.2026.5879
Cited by: 1
References: 47

Abstract

, oral administration of IPA markedly improved trabecular bone microarchitecture, enhanced bone formation, and corrected marrow adiposity without detectable systemic toxicity. Collectively, the present findings identified IPA as a previously under‑recognised microbiota‑derived metabolite that maintains skeletal homeostasis by restoring the osteogenic‑adipogenic balance through suppression of PPARγ signalling. The present study uncovers a mechanistic link between gut microbial metabolism and BMSC fate regulation and highlights IPA as a promising therapeutic candidate for OP.

Fields of Study & Subjects

Bone Metabolism and Diseases Immune responses and vaccinations Gut microbiota and health

Publication details

Journal / source
International Journal of Molecular Medicine
Publisher
Spandidos Publications
Volume
58
Issue
2
Pages
1–15
Publication date
3 June 2026
Language
EN