Echinacoside alleviates asthenozoospermia by upregulating Sox5‑mediated transcriptional activation of the CatSper gene

Molecular Medicine Reports 2026 Open access

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Authors: Zi-Run Jin, Yongwei Huo, Bo-Heng Liu, Hong Tian, Shuo Yuan, Yue Tian, Ke Xi, Jie Cai, Hui Jiang, Yong Jiang, Guo‐Gang Xing
DOI: 10.3892/mmr.2026.13794
Cited by: 2
References: 62

Abstract

results further suggested that ECH treatment improved sperm motility and CatSper function in the sperm samples from both healthy subjects and patients with idiopathic AZS (iAZS). The present findings suggest that ECH treatment exerts certain therapeutic effects on iAZS through the functional upregulation of CatSper channels in the sperm. These findings position ECH as a promising complementary and alternative medicine therapeutic for enhancing sperm function and managing iAZS in clinical practice. .

Fields of Study & Subjects

Sperm and Testicular Function Plant Reproductive Biology Connexins and lens biology

Publication details

Journal / source
Molecular Medicine Reports
Publisher
Spandidos Publications
Volume
33
Issue
3
Publication date
12 January 2026
Language
EN