CTRP4 ameliorates dexamethasone‑induced insulin resistance through the IRS‑1/PI3K/AKT pathway in 3T3‑L1 adipocytes

Molecular Medicine Reports 2026

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Authors: Maireyanmu Rouzi, Xi Sun, Luguang Sheng, Bilin Xu, Tao Lei, Jun Lu, Jie Gao
DOI: 10.3892/mmr.2026.13811
Cited by: 1
References: 46

Abstract

(HOMA‑IR) were evaluated using Spearman's correlation analysis. Recombinant CTRP4 protein was administered to fully differentiated 3T3‑L1 adipocytes to explore the impact of CTRP4 on lipid accumulation. In addition, the effects of CTRP4 on restoring impaired glucose uptake were examined through the glucose oxidase‑peroxidase method. Molecular marker expression levels in the insulin signaling pathway, in 3T3‑L1 adipocytes with IR induced by 1 µM dexamethasone, were also examined, through western blotting. The expression levels of CTRP4 exhibited a negative association with body mass index (r=‑0.35; P

Fields of Study & Subjects

Adipokines Inflammation and Metabolic Diseases Adipose Tissue and Metabolism Metabolism Diabetes and Cancer

Publication details

Journal / source
Molecular Medicine Reports
Publisher
Spandidos Publications
Volume
33
Issue
3
Pages
1–8
Publication date
27 January 2026
Language
EN