Endostar combined with docetaxel or cisplatin in the management of malignant ascites through hyperthermic intraperitoneal chemotherapy: A retrospective cohort study

Peritoneal metastases (PM) are a prevalent and treatment-resistant form of recurrence in patients with abdominal tumors. The present study retrospectively examined the clinical performance and potential adverse effects of combining Endostar with docetaxel/cisplatin chemotherapeutic hyperthermic intraperitoneal chemotherapy (HIPEC) for treating malignant ascites (MA). Subjects diagnosed with malignancies confirmed by ascites cell block results and clinical presentations were included within the study, constituting a total of 48 MA cases. The docetaxel group (n=25) was treated with Endostar combined with docetaxel for two cycles. The cisplatin group (n=23) was treated with Endostar combined with cisplatin for two cycles. The objective response rate (ORR; defined as CR + PR), disease control rate (DCR; defined as CR + PR + SD), ascites control time, improvement rate of the Karnofsky Performance Status (KPS) and incidence of major adverse reactions were statistically analyzed. There were no significant differences in the ORR (64.0 vs. 56.5%), DCR (92.0 vs. 91.3%), improvement rate of KPS (48.0 vs. 43.5%) or ascites control time (55 vs. 46 days) between the docetaxel and cisplatin groups (all P>0.05). Renal function impairment developed in 7 patients (30.4%) in the cisplatin group compared with 1 patient (4.0%) in the docetaxel group (P