GPR176 enhances the epithelial‑mesenchymal transition in gastric cancer cells by activating the PI3K/AKT/mTOR signaling pathway

Oncology Reports 2026 Open access

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Authors: Guangchuan Mu, Kaiyan Li, Chaozhen Hu, Jintao Cai, Huichao Ruan, Guanyu Zhu, Dang Liu
DOI: 10.3892/or.2026.9053
Cited by: 1
References: 63

Abstract

, while GPR176 overexpression led to activation of these pathways. In summary, the present study identifies GPR176 as a novel prognostic biomarker in gastric cancer. Mechanistically, GPR176 promotes EMT and tumor progression, at least in part, through activation of the PI3K/AKT/mTOR signaling pathway.

Fields of Study & Subjects

Receptor Mechanisms and Signaling Cancer Lipids and Metabolism Estrogen and related hormone effects

Publication details

Journal / source
Oncology Reports
Publisher
Spandidos Publications
Volume
55
Issue
3
Pages
1–17
Publication date
19 January 2026
Language
EN