Normalizing Uricemia in Psoriatic Arthritis: A Hypothetical Reduction of Atherosclerotic Plaque Burden

The Journal of Rheumatology 2026 Open access

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Authors: Rubén Queiro, Marta Loredo, Estefanía Pardo, Ignacio Braña
DOI: 10.3899/jrheum.2025-0992
Cited by: 1
References: 8

Abstract

Hyperuricemia has long been recognized as the biochemical substrate for gout, but growing evidence suggests that it may also contribute to cardiovascular (CV) disease. Psoriatic inflammation, dominated by interleukin (IL)-23/IL-17 and tumor necrosis factor, amplifies endothelial activation (increase in vascular cell adhesion molecule 1), oxidative stress, and neutrophil extracellular trap formation (ie, NETosis), priming the arterial wall for atherogenesis.

Fields of Study & Subjects

Gout Hyperuricemia Uric Acid Inflammasome and immune disorders Spondyloarthritis Studies and Treatments

Publication details

Journal / source
The Journal of Rheumatology
Publisher
The Journal of Rheumatology
Volume
53
Issue
5
Pages
580–581
Publication date
15 February 2026
Language
EN