Complement inhibition: A whole new world

Cleveland Clinic Journal of Medicine 2026 Open access

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Authors: Nicholas Salupo, Korey Bartolomeo, Elias Bassil, Corey J. Cavanaugh, Georges Nakhoul, Jonathan J. Taliercio, Ali Mehdi
DOI: 10.3949/ccjm.93a.25076
Cited by: 1

Abstract

The complement system is a central component of the innate immune system, and it is a bridge to the adaptive immune system. With this broad functional reach, dysregulation of this system contributes to a wide range of inflammatory and autoimmune conditions. Drugs that inhibit the complement system have dramatically improved outcomes in many previously untreatable diseases, and the number of approved indications is growing rapidly, requiring specialists and generalists alike to be familiar with these drugs.

Fields of Study & Subjects

Complement system in diseases Immune responses and vaccinations Monoclonal and Polyclonal Antibodies Research

Publication details

Journal / source
Cleveland Clinic Journal of Medicine
Publisher
Cleveland Clinic Journal of Medicine
Volume
93
Issue
4
Pages
227–236
Publication date
1 April 2026
Language
EN