Clinicopathological features of gastric Langerhans cell histiocytosis and a literature review

Journal of the Japan Society of the Reticuloendothelial System 2026 Open access

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Authors: Xue Chen, Yunjin Wu, X L Wang, Muye Yang, Xiaoxiang Gao, Suxia Zhang, Huihui Sun, Yunhui Zhang, Hongmei Yi, Y X Zeng
DOI: 10.3960/jslrt.25082
Cited by: 0
References: 32

Abstract

Objective This study aims to review the clinicopathological features, molecular profiles, and clinical behavior of gastric LCH to increase diagnostic accuracy and improve the understanding of its prognosis. Methods We analyzed five cases of gastric LCH and integrated clinical, endoscopic, and pathological data. Diagnoses were confirmed via immunohistochemistry (S-100, CD1a, and Langerin). BRAF-V600E mutation status was assessed by PCR in three patients. A literature review of 17 additional cases was included for a comprehensive analysis. Results Patients presented with nonspecific symptoms such as abdominal pain. Endoscopy predominantly revealed solitary polyps (

Fields of Study & Subjects

Histiocytic Disorders and Treatments Gastrointestinal Tumor Research and Treatment Vascular Malformations and Hemangiomas

Publication details

Journal / source
Journal of the Japan Society of the Reticuloendothelial System
Volume
66
Issue
1
Pages
11–18
Publication date
1 January 2026
Language
EN