Integrated Microbiome and Metabolomic Profiling to Identify Potential Biomarkers of Major Depressive Disorder
Abstract
in MDD patients. Integrated correlation analysis revealed a functional "gut-lipid axis", where these taxa were strongly associated with alterations in host acylcarnitine and fatty acid metabolism. Notably, diagnostic evaluation demonstrated that the plasma metabolic profile yielded superior predictive accuracy (AUC = 0.862) compared to the gut microbiota (AUC = 0.654). Our findings suggest that while the gut microbiome provides mechanistic insights into lipid dysregulation, the circulating metabolome serves as a more robust, proximal diagnostic readout for MDD.
Fields of Study & Subjects
Gut microbiota and health
Metabolomics and Mass Spectrometry Studies
Tryptophan and brain disorders
Publication details
- Journal / source
- Journal of Microbiology and Biotechnology
- Publisher
- Korean Society for Microbiology and Biotechnology
- Volume
- 36
- Pages
- e2512014–e2512014
- Publication date
- 22 January 2026
- Language
- EN