Computer Modeling of Induced Hyperthermia Using Superparamagnetic Iron Oxide Nanoparticles and their Application

The goal of this research is to develop the mathematical realization of RF-induced hyperthermia models for the effective ablation of brain tumors. This process requires a precise evaluation of the magnetic field interactions with the SuperParamagnetic Iron Oxide (SPIO) nanoparticles. The nanoparticles are suspended in a gelatin that can emulate several properties of brain tissue. The physical system, Hot Shot RF Unit, developed by Ameritherm Inc. that produces an AC magnetic field through induction, is used for empirical data acquisition. The magnetic fluid is subjected to an alternating field whereby the magnetic moments of these single domain particles are constantly oscillating and resulting in frictional heat losses. With the development of a targeting ligand for efficient biodistribution, these particles would adhere to the neoplasm and destroy the tumor through controlled RF exposure. The first step in realizing the above-mentioned effects is to develop a model that can estimate the potential effects of changing certain parameters such as coil diameter, time of exposure, and field strength for future optimization.