Liver Imaging Reporting and Data System: current status and future perspectives in the diagnosis of hepatocellular carcinoma

Italian Journal of Medicine 2026 Open access

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Authors: Guido Faggian, Roberto Faggian, Michela Salzano, Ciro Stavolo, Teresa Argenziano, Alessia Argenziano, Andrea Diglio, Angela Faggian
DOI: 10.4081/itjm.2026.2413
Cited by: 1
References: 30

Abstract

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and ranks third among cancer-related deaths globally, with over 900,000 new cases and approximately 830,000 deaths annually. Early detection is crucial, as 5-year survival exceeds 70% for lesions 95% positive predictive value for HCC. Meta-analyses of over 3300 observations report 86% sensitivity and 85% specificity for computed tomography/magnetic resonance imaging (MRI) LI-RADS, with gadoxetate-enhanced MRI reaching 88-91% sensitivity. Key limitations include overcalling benign hypervascular nodules, underdiagnosing hypovascular or well-differentiated HCC (up to 30% of lesions

Fields of Study & Subjects

Hepatocellular Carcinoma Treatment and Prognosis Radiomics and Machine Learning in Medical Imaging Cholangiocarcinoma and Gallbladder Cancer Studies

Publication details

Journal / source
Italian Journal of Medicine
Publisher
PAGEPress Publications
Volume
20
Issue
1
Publication date
15 January 2026
Language
EN