Mixed Diphenhydramine and Dextromethorphan Overdose Resulting in Serotonin Toxicity

The Primary Care Companion For CNS Disorders 2026

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Authors: Ann C. Schwartz, Nicole K. Delgado, Gregg A. Robbins-Welty
DOI: 10.4088/pcc.25cr04166
Cited by: 1

Abstract

The authors describe a case of intentional overdose with diphenhydramine and extended-release dextromethorphan-guaifenesin that initially presented with anticholinergic toxicity and later evolved into serotonin toxicity.

Fields of Study & Subjects

Respiratory and Cough-Related Research Poisoning and overdose treatments Takotsubo Cardiomyopathy and Associated Phenomena

Publication details

Journal / source
The Primary Care Companion For CNS Disorders
Publisher
Physicians Postgraduate Press, Inc
Volume
28
Issue
2
Publication date
28 April 2026
Language
EN