Not your usual drug-induced liver injury: Dolutegravir-associated granulomatous hepatitis

Southern African Journal of HIV Medicine 2026 Open access

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Authors: Muhammed Vally, Muhammad Ayob, Adam Mahomed, Kairoonisha Mahomed, Washington Mudini, Vikash G. Lala
DOI: 10.4102/sajhivmed.v27i1.1817
Cited by: 1
References: 9

Abstract

Dolutegravir is an integrase inhibitor in first-line antiretroviral therapy in South Africa. We describe a patient who developed severe drug-induced liver injury on dolutegravir-containing antiretroviral treatment, in whom liver biopsy demonstrated subacute hepatic necrosis, non-necrotising granulomatous inflammation, and bile duct injury: an uncommon histological pattern in dolutegravir-associated hepatotoxicity.

Fields of Study & Subjects

Drug-Induced Hepatotoxicity and Protection Pneumocystis jirovecii pneumonia detection and treatment Hepatitis C virus research

Publication details

Journal / source
Southern African Journal of HIV Medicine
Publisher
AOSIS
Volume
27
Issue
1
Pages
1817–1817
Publication date
25 June 2026
Language
EN