Acute G6PD deficiency haemolytic crises with associated methaemoglobinaemia in a patient with typhoid
Abstract
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked disorder that increases red blood cell susceptibility to oxidative damage. While haemolysis is common, methaemoglobinaemia is a rare complication. A 39-year-old man developed both conditions, triggered by Salmonella typhi infection. Diagnosis was supported by Heinz bodies and blister cells on blood smear. Methylene blue and high-dose ascorbic acid were relatively contraindicated because of ongoing haemolysis and renal dysfunction. Contribution: This case highlights the importance of considering methaemoglobinaemia in G6PD deficiency during infections and adapting treatment when standard therapies are unsuitable.
Fields of Study & Subjects
Methemoglobinemia and Tumor Lysis Syndrome
Neonatal Health and Biochemistry
Neutropenia and Cancer Infections
Publication details
- Journal / source
- Southern African Journal of Infectious Diseases
- Volume
- 41
- Issue
- 1
- Pages
- 771–771
- Publication date
- 9 January 2026
- Language
- EN