Acute Marchiafava–Bignami Disease Linked to Tea and Toast Diet: A Case Report
Abstract
Marchiafava-Bignami disease (MBD) is a rare demyelinating disorder primarily associated with chronic alcoholism. We present a case of a nonalcoholic patient who developed acute cognitive decline secondary to severe dietary deficiency. Magnetic resonance imaging (MRI) demonstrated an isolated, symmetric lesion in the central corpus callosum, differentiating MBD from acute infarction. Rapid improvement followed Vitamin B supplementation, emphasizing the need for early recognition and treatment. This case expands the clinical spectrum of MBD and underscores the crucial role of MRI in diagnosis and prognosis.
Fields of Study & Subjects
Alcoholism and Thiamine Deficiency
Folate and B Vitamins Research
Neurological diseases and metabolism
Publication details
- Journal / source
- Acta Neurologica Taiwanica
- Volume
- 35
- Issue
- 1
- Pages
- 53–55
- Publication date
- 1 January 2026
- Language
- EN