Multicentric Reticulohistiocytosis: A Report of Two Cases

Clinical Dermatology Review 2026 Open access

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Authors: Soudamini Rajesh Tiwari, Pallavi Jagdish Yede, PallaviRupkumar Rokade, Bhagyashree Babanrao Supekar, Jayesh Ishwardas Mukhi
DOI: 10.4103/cdr.cdr_30_25
Cited by: 0
References: 11

Abstract

Multicentric reticulohistiocytosis (MRH) is a rare histiocytic disorder with cutaneous and joint manifestations that most commonly affect middle-aged women. It is often misidentified as more common arthropathies and skin conditions, such as rheumatoid arthritis, dermatofibromas, progressive nodular histiocytomas, gouty tophi, and sarcoidosis, leading to incorrect treatment approaches. Here, we report two cases of MRH, diagnosed based on clinical and histopathological findings, who showed a significant response with the treatment of weekly methotrexate and tapering oral steroids.

Fields of Study & Subjects

Histiocytic Disorders and Treatments Cutaneous lymphoproliferative disorders research Tuberous Sclerosis Complex Research

Publication details

Journal / source
Clinical Dermatology Review
Volume
10
Issue
1
Pages
63–66
Publication date
1 January 2026
Language
EN