Incomplete Netherton Syndrome treated successfully with Isotretinoin
Abstract
Netherton syndrome is a rare autosomal recessive ichthyosis caused by serine peptidase inhibitor Kazal 5 mutation, characterized by congenital ichthyosis, trichorrhexis invaginata, atopy, high serum immunoglobulin E levels, and hyper eosinophilia. The demonstration of bamboo hair by microscopy is used as a method to diagnose Netherton syndrome. We report a rare patient with Netherton syndrome confirmed by genetic analysis and protein expression studies who had normal hair and was successfully treated with low dose isotretinoin, without any adverse events.
Fields of Study & Subjects
Skin and Cellular Biology Research
Proteoglycans and glycosaminoglycans research
Cell Adhesion Molecules Research
Publication details
- Journal / source
- Clinical Dermatology Review
- Volume
- 10
- Issue
- 1
- Pages
- 67–69
- Publication date
- 1 January 2026
- Language
- EN