Comparison of the Hypotension Prediction Index and pulse pressure variation-guided haemodynamic management for intra-operative hypotension during kidney transplant: A randomised controlled trial
Abstract
Background and Aims: Intra-operative hypotension (IOH) adversely affects renal graft and recipient outcomes. The Hypotension Prediction Index (HPI), a machine learning-based algorithm, predicts IOH. This study compared HPI- versus pulse pressure variation (PPV)-guided haemodynamic management in kidney transplantation, hypothesising that HPI guidance would reduce intra-operative hypotension. Methods: In this single-centre randomised controlled trial, 82 patients with end-stage renal disease (ESRD) undergoing live-related kidney transplantation under general anaesthesia were randomised to HPI-guided ( n = 41) or PPV-guided ( n = 41) haemodynamic management. The primary outcome was the time-weighted average area under the threshold (TWA-AUT) of mean arterial pressure (MAP)
Fields of Study & Subjects
Hemodynamic Monitoring and Therapy
Renal and Vascular Pathologies
Sepsis Diagnosis and Treatment
Publication details
- Journal / source
- Indian Journal of Anaesthesia
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Volume
- 70
- Issue
- Suppl 1
- Pages
- S50–S58
- Publication date
- 1 January 2026
- Language
- EN