Comparison of dexmedetomidine, haloperidol, and propofol sedation on intra-abdominal pressure, inflammatory response, and clinical outcomes in patients with abdominal sepsis: A randomised controlled study

Background and Aims: Abdominal sepsis serves as a significant challenge in critical care and frequently requires mechanical ventilation (MV) and sedation to ensure patient satisfaction and promote recovery. The present research compared the effect of dexmedetomidine, haloperidol, and propofol on intra-abdominal pressure (IAP), inflammatory markers, and clinical outcomes in abdominal septic cases. Methods: This randomised controlled trial enroled 90 adult abdominal sepsis patients requiring postoperative MV. Patients were randomised to three groups: Group D received intravenous (IV) dexmedetomidine (1 μg/kg loading dose over 10 min; 0.2–0.3 μg/kg/h maintenance), Group H was administered IV haloperidol (2.5 mg loading dose; 1–2 mg/h infusion), and Group P received IV propofol (1 mg/kg loading dose over 15 min; 20–80 μg/kg/min maintenance). The primary outcome was the serum interleukin (IL)-6 level at 24 hours. Data were analysed using one-way analysis of variance (ANOVA), Tukey’s post hoc test, Kruskal–Wallis test, or Chi-square test as appropriate, with a P value