ABSTRACT FOR PROFESSOR M. MURUGAPPAN POSTER SESSION II AWARD

Real-time lives, real-time data: Ecological momentary assessment for alcohol dependence in India Ankita Chattopadhyay, Shalini Singh1, Rakesh Lal1 Department of Psychiatry, Institute of Human Behaviour and Allied Sciences, 1National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, India E-mail: [email protected] Aims and Objectives: Real-time behavioural monitoring in substance-using population via Ecological momentary assessment (EMA) is emerging as a valuable method for assessing in natural settings. However, most EMA research is being conducted in developed countries and predominantly among non-dependent or non-treatment-seeking individuals, often with varied protocols and heterogeneous samples. This study aims to explore feasibility of EMA in treatment-seeking alcohol-dependent patients in India. Methods: A total of 102 males diagnosed with alcohol-dependence were recruited during outpatient detoxification phase. Ethical approval was obtained, and participants provided written informed consent. Participants completed a socio-demographic-clinical proforma, along with assessment of alcohol use severity, affective states (depression, anxiety, psychological stress), and alcohol craving using standardized clinical scales. EMA prompts assessing mood (sadness), anxiety, stress, and craving were sent to participants’ phones thrice daily for one week. Additionally, participants were required to self-initiate a response once daily. Results: Overall response rate was 24.47%, comprising 0.08% for self-initiated responses and 32.35% for random prompts. Acceptance rate for participation was high at 91.07%, but retention rate was low (34.31%). Compliance assessed by tracking response frequency revealed decline in responses over study duration. Feedback from participants indicated that both the length and frequency of assessments were perceived as “just right.” Notably, no significant clinical differences emerged between responders and non-responders. Reliability analysis showed moderate reliability for mood and stress measures, but poor reliability for anxiety and craving. Discussion: This study is pioneering in assessing EMA feasibility among treatment-seeking alcohol- dependent patients in India, highlighting the strengths as well as challenges in using EMA for monitoring drinking behaviour and related parameters. Conclusion: EMA studies involving larger samples and strategies to enhance adherence, such as incentivization and personalized interventions should be conducted in India. Additionally, developing tailored digital applications for alcohol-dependent patients in India could improve efficacy of EMA methodologies. Attitudes, motives and personality characteristic of living kidney donors: An exploratory study Bhupendra Singh Thakur, M. K. Sahu, Surbhi Dubey Department of Psychiatry, Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India Aim: To assess the motives, attitudes, and personality characteristics of living kidney donors. Objectives: The study aimed to explore the motivations and attitudes of living kidney donors, identify their dominant personality characteristics, and examine the diversity of kidney donation experiences across different subcategories of donors. Methodology: A mixed-method exploratory study was conducted at Dr. B.R.A.M. Hospital, Raipur, from October 2023 to March 2025. Sixty-three (63) prospective living kidney donors were recruited. Data collection included narrative interviews, the Live Donor Assessment Tool (LDAT) for psychosocial evaluation, and the Personality Inventory for ICD-11 (PiCD) for personality assessment. Quantitative data were analysed descriptively, while qualitative data were thematically analysed to identify key motivational and emotional patterns. Results: The mean age of donors was 43.75 years; most were female (68.25%), married (82.54%), from lower-middle socioeconomic backgrounds (57.14%), and urban residents (53.97%). Spouses, siblings, and parents were the main donor groups. LDAT scores reflected moderate psychosocial risk overall, with strong mental health, stability, and social support, but weaker knowledge and post-donation expectations. PiCD results showed Anankastia as the dominant personality trait, while Dissociality was minimal. Spouse donors demonstrated the highest psychosocial preparedness. Qualitative findings identified five motivational themes: familial obligation, spiritual beliefs, altruism, moral pride, and social or gender expectations. Discussion: Living kidney donors demonstrated strong motivation, emotional stability, and family-driven commitment, with conscientious (Anankastia) traits supporting donation suitability. However, limited knowledge, emotional conflicts, and moderate psychosocial risk persisted. Family and cultural influences significantly shaped donor decisions, emphasizing the need for structured psychosocial screening and culturally sensitive counselling. Conclusions: Despite psychological readiness and altruistic motivation, gaps in knowledge and emotional concerns remain among living kidney donors. Comprehensive psychosocial assessment, targeted counselling, and enhanced donor education are essential to ensure ethical, informed, and emotionally safe kidney donation. Key words: Anankastia, attitudes, ICD-11, live donor assessment tool, living kidney donors, motives, personality traits, psychosocial assessment Menopausal transition and menopause among women with severe mental illness; An exploratory study B. Inchara, Sundarnag Ganjekar, A. Rashmi, Lata Venkataram1, Geetha Desai Department of Psychiatry, NIMHANS, 1Department of Obstetrics and Gynaecology, Rangadorai Hospital, Bengaluru, Karnataka, India Background: The protective role of estrogen in women with severe mental illness (SMI) has been documented. Menopausal transition is associated with declining estrogen levels and worsening of symptoms, relapse and poor response to treatment. Aim: To study the experience of menopausal transition (MT) and menopause among women with SMI. Methodology: A cross-sectional exploratory study was conducted at NIMHANS involving 147 women with age of 40-55 yrs, ICD-10 diagnosis of Bipolar disorder (BD), Severe Depression, Recurrent Depressive disorder, Schizophrenia and related disorders with illness onset preceding perimenopause. Using Stages of Reproductive Aging Workshop (STRAW), their menstrual transition was determined. Menopausal Rating Scale (MRS) and Brief Psychiatric Rating Scales (BPRS) were used to assess the menopausal symptoms and current psychiatric symptoms respectively. Descriptive and inferential statistics (Chi-square, Mann Whitney U, Spearman correlation) were used. Results: Among 147 women (mean age: 47.7±4 yrs, mean duration of illness: 23.2±5.3 yrs), 38 (25.9%) were in early MT, 24 (16.3%) in late MT and 85 (57.8%) in menopause, with diagnoses of schizophrenia 77 (52.38%), bipolar disorder 43 (29.3%), and depressive disorder 27 (18.4%), among them 109 (74.1%) were treatment adherent. Mean MRS score was 19.85 ± 6.0. The mean BPRS score was 27.8±4.8, with mean score highest in anxiety/depression (10.81± 3.17) and during late MT (29.54± 5.53). Around 43 (29.3%) reported worsening of psychiatric symptoms, and 83 (56.5%) needed medication adjustments for symptom control. BPRS total scores showed significant positive correlation with MRS total scores (rs=0.382, p-value < 0.001). Discussion and Conclusion: Menopause and its transition seems to be associated with increase in psychiatric symptoms, necessitating medication adjustments. Positive correlation observed between psychiatric and menopausal symptoms indicate that menopausal symptoms too require close monitoring in women. Efficacy of low-frequency rTMS over SMA versus high-frequency rTMS over left DLPFC in OCD: A head-to-head randomized controlled trial Jayashree Kalita, Sukanto Sarkar, Aniruddha Basu, Kumari Rina, Arkapal Bandyopadhyay, Apurba Mahato All India Institute of Medical Sciences, Kalyani, West Bengal, India Background: OCD is a chronic and disabling condition with a global prevalence of 2–3%. Although selective serotonin reuptake inhibitors are widely used, they benefit only 40–60% of patients and require several weeks for response. rTMS has shown comparable efficacy with earlier onset with stronger evidence for L-f rTMS over SMA and H-f rTMS over the LDLPFC. Aim: To compare the efficacy of low-frequency rTMS over the supplementary motor area (SMA) versus high-frequency rTMS over the left dorsolateral prefrontal cortex (L-DLPFC) in patients with obsessive–compulsive disorder (OCD). Objectives: The primary objective was to assess changes in obsessive-compulsive symptom severity measured by reduction in Y-BOCS scores from baseline (T1) to post-intervention (T2) and one-month follow-up (T3) along with response rates in both the groups defined by OCD Consortium criteria at above mentioned time points. Secondary objectives included evaluating changes in depressive and anxiety symptoms (HAM-D, HAM-A) and global severity (CGI-S) from baseline to both time-points, T2 and T3. Methods: The study was approved by the Institutional Ethics Committee and registered under Clinical Trials Registry of India ( CTRI/2024/05/067470). 42 participants aged 18–60 years with Y-BOCS ≥16, CGI ≥3 and stable medications for ≥4 weeks were allocated to receive either 1 Hz rTMS over SMA (1200 pulses/day) or 10 Hz rTMS over L-DLPFC (1500 pulses/day) for 10 sessions by block randomisation. Assessments (Y-BOCS, CGI-I, CGI-S, HAM-D and HAM-A) were conducted at baseline, post-intervention and at one-month of follow-up. Results: Both groups demonstrated significant reduction in Y-BOCS score (p3), were randomised via computer-generated permuted block randomisation and allocation concealment using sequence-numbered opaque sealed envelopes (SNOSE) to receive either anodal (AT) or sham (ST) tDCS (10 twice-daily sessions over 5 days; 2 mA, 20 min each). Pain outcomes were measured using the Brief Pain Inventory (BPI), depressive and anxiety symptoms with Hamilton scales (HAM-D, HAM-A) at baseline (T0), immediately post-intervention (T10), and one-month post-intervention (T1M). Cortical reactivity was assessed using TMS-EMG indices such as motor threshold (MT) and corticospinal silent period (CSP) at T0 and T10. Results: Of 40 participants (95% male; aged 30.9±7.4 years), 87.5% completed the study (AT=19; ST=16). Compared to ST, AT led to significantly greater pain reduction at T1M (time* intervention effects, F=7.34, p=0.01) but not at T10. Similarly, AT significantly decreased MT (time* intervention effects, F=9.05, p