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Adverse childhood experiences and substance use disorder in adult life in patients attending a tertiary care institute in north-eastern India Aahel Bandyopadhyay King George Medical University, Lucknow, Uttar Pradesh, India Background: Substance use disorder (SUD) is a widely prevalent condition worldwide. Studies have found that childhood adversities are one of the key factors leading to the changes in neural networks, impaired endocrine and immune system development resulting in chronic physiological dysfunction. There are only a few studies reporting relationship between adverse childhood experiences (ACEs) and SUD in India. Aim: To assess the impact (if any) of adverse childhood experiences on substance use disorder in adult life. Methods: Observational and descriptive study with sample size 150 was conducted among patients having SUD of age group 18-60 years attending Department of Psychiatry, Regional Institute of Medical Sciences, Imphal, Manipur during May 2022 to June 2024. Study tools were semi structured questionnaire for socio demographic profile, DSM-5 diagnostic criteria for diagnosis and severity of SUD, semi-structured proforma for type and pattern of substance use, Adverse Childhood Experiences International Questionnaire for assessing childhood trauma of subjects. Results: Among the subjects with alcohol and opioid use disorder, significant difference existed between those who had experienced ACEs and who had not in the domains of community violence, contact sexual abuse, history of alcohol &/or drug abuser in household etc. along with significant difference in mean total ACE score showing that severity of alcohol and opioid dependence increases with increase in total ACE score. Conclusion: This study emphasises need for life-course approach to mental health and substance use prevention, integrating early childhood interventions with adult treatment programs to break the cycle of childhood adversity and addiction. Effectiveness of neuro-cognitive plasticity therapy on cognitive distortions in major depressive disorder Aakriti Varshney, Anand Pratap Singh Department of Psychology and Mental Health, Gautam Buddha University, Greater Noida, Uttar Pradesh, India Background: Cognitive distortions are automatic, maladaptive thought patterns that contribute to the onset and persistence of Major Depressive Disorder. These distortions are not only psychological constructs, but are also rooted in dysfunctional neural connectivity within specific brain networks. Aim: The present study evaluated the effectiveness of neuro-cognitive plasticity therapy in reducing cognitive distortions and negative automatic thoughts in adults with MDD using a pre-post experimental design as part of a preliminary pilot investigation. Method: Twenty-four participants diagnosed with MDD administered the Cognitive Distortion Scale (CDS) and Automatic Thoughts Questionnaire-Negative (ATQ-N) before and after a 6-week intervention of NCPT. Results: The results indicated a significant reduction in CDS total scores (t = 7.84, p < .001, Cohen’s d = 1.60) and ATQ-N total scores (t = 6.92, p < .001, Cohen’s d = 1.41). Conclusion: NCPT was found to be effective in carrying a significant reduction in maladaptive thinking patterns and negative automatic thoughts in patients with MDD, supporting its potential as an integrative therapeutic approach. Assessing quality of life in patients with idiopathic generalized epilepsy: A cross sectional study from a tertiary care hospital in Jabalpur Aanchal Gupta, Namrata Khandelwal, Aftab Ahmed Khan NSCB Medical College and Hospital, Jabalpur, Madhya Pradesh, India Background: Idiopathic Generalized Epilepsies (IGEs) represent a major subset of genetic epilepsies, predominantly affecting adolescents and young adults. Quality of life (QOL) in individuals with epilepsy is significantly influenced by psychiatric comorbidities, medication side effects, and seizure-related factors, but remains understudied in Indian populations. Methods: Ethical clearance was obtained from the Instituional Ethics Committee, No. IEC/2023/7335-69. A cross-sectional observational study was conducted on 69 individuals aged 10-65 years diagnosed with IGE at a tertiary care centre in Central India. Sociodemographic and clinical details were recorded. The Quality of Life in Epilepsy Inventory-31 (QOLIE-31) was administered to assess health-related QOL. Statistical analyses included t-tests, ANOVA, and correlation tests to explore associations between QOL and clinical variables. Results: Over half of the participants (52.2%) had moderate QOLIE-31 scores (40-59), while 15.9% had poor scores (