Disulfiram resistance in alcohol dependence: Myth or reality?
Abstract
Alcohol use is a major public health concern in India. Disulfiram is one of the few effective drugs approved for treatment of alcohol use disorder. There have been a few, if any, research studies on resistance to disulfiram as well as other nondeterrent effects of the drug. Here, we shall discuss three cases with disulfiram resistance, with one of them having possible anticraving effect, and also reflect on probable etiologies leading to this unexpected phenomenon. In this context, more research is needed into how different populations and ethnic/racial groups respond to this medication.
Fields of Study & Subjects
Substance Abuse Treatment and Outcomes
Alcohol Consumption and Health Effects
Alcoholism and Thiamine Deficiency
Publication details
- Journal / source
- Industrial Psychiatry Journal
- Volume
- 35
- Issue
- 1
- Pages
- 158–160
- Publication date
- 1 January 2026
- Language
- EN