Baseline serum 25-hydroxyvitamin D levels as a predictor of periapical healing and clinical success after primary root canal treatment: A prospective, observational, and cohort study

Journal of Conservative Dentistry and Endodontics 2026 Open access

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Authors: Manish R. Sharma, Monali Nikalje, Rahul Tiwari, Sanghamitra Jena, Harisha Dewan, Mohammed Mustafa
DOI: 10.4103/jcde.jcde_141_26
Cited by: 1
References: 21

Abstract

Abstract Background: Systemic host factors, such as serum 25-hydroxyvitamin D(25[OH]D), may influence periapical healing after root canal treatment (RCT); however, prospective clinical evidence remains limited. Aim: To evaluate whether baseline serum 25(OH)D levels predict periapical healing and 12-month clinical success following a primary RCT. Materials and Methods: Ninety systemically healthy adults (18–50 years old) requiring primary RCT of single-rooted teeth were enrolled. Participants were categorized as Vitamin D–deficient (

Fields of Study & Subjects

Endodontics and Root Canal Treatments Dental Erosion and Treatment Dental Radiography and Imaging

Publication details

Journal / source
Journal of Conservative Dentistry and Endodontics
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
29
Issue
5
Pages
485–490
Publication date
30 April 2026
Language
EN