Stool Sphingomyelins as Biomarkers of Cholestasis and Inflammation in Very-low-birth Weight Neonates: A Cohort Study

Journal of Clinical Neonatology 2026 Open access

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Authors: Ari J. Esrig, Arpitha Shenoy, Glynis L. Kolling, Andrea S. Marrs, Jason A. Papin, Sean R. Moore, Brynne A. Sullivan
DOI: 10.4103/jcn.jcn_107_25
Cited by: 0
References: 20

Abstract

Background: Very low birth weight (VLBW) neonates are at increased risk for developing inflammatory conditions, complications from parenteral nutrition (PN), and cholestasis. Clinicians lack reliable, noninvasive biomarkers to monitor these conditions effectively. Fecal metabolomics, particularly the targeted analysis of sphingomyelins, presents a promising noninvasive diagnostic strategy to evaluate both intestinal and systemic health in this population. Methods: This prospective cohort study enrolled 45 preterm infants weighing

Fields of Study & Subjects

Infant Nutrition and Health Neonatal Respiratory Health Research Clinical Nutrition and Gastroenterology

Publication details

Journal / source
Journal of Clinical Neonatology
Volume
15
Issue
1
Pages
34–41
Publication date
1 January 2026
Language
EN