Multimodal imaging of isotretinoin-induced retinal pigment epithelium atrophy and keratoconus
Abstract
Isotretinoin is a US Food and Drug Administration-approved drug for the management of acne vulgaris. However, it is associated with various ophthalmic side effects. Herein, we report a case of a 31-year-old female presenting with blurring of vision after the use of isotretinoin. Ocular tomography confirmed the keratoconus, whereas optical coherence tomography was suggestive of retinal pigment epithelium (RPE) atrophy. Electroretinogram also revealed reduced macular cone photoreceptor functions due to toxic maculopathy.
Fields of Study & Subjects
Drug-Induced Ocular Toxicity
Retinal Diseases and Treatments
Retinal Development and Disorders
Publication details
- Journal / source
- Journal of Clinical Ophthalmology and Research
- Volume
- 14
- Issue
- 1
- Pages
- 60–62
- Publication date
- 1 January 2026
- Language
- EN