Bacillary angiomatosis in an 8-year-old child with dedicator of cytokinesis 8-deficient autosomal recessive hyper-IgE syndrome: case report

Bacillary angiomatosis (BA) is a vasculoproliferative infection caused by Bartonella henselae or Bartonella quintana , typically arising in immunocompromised individuals, particularly those with advanced HIV infection. The occurrence of BA in pediatric patients with primary immunodeficiency disorders is extremely rare. Herein, we report the first known case of BA in an 8-year-old boy with dedicator of cytokinesis 8-deficient autosomal recessive hyper-IgE syndrome. The patient developed multiple angiomatous nodules on the face, retroauricular area, and genitalia after a scratch from a domestic kitten. Diagnosis was confirmed through histopathological examination and PCR detection of Bartonella henselae DNA. The patient responded favorably to oral azithromycin. This case underscores the importance of considering BA in the differential diagnosis of vascular skin lesions in patients with inborn errors of immunity and highlights the need for prompt antimicrobial treatment to avoid systemic complications.