Elevated serum heat shock protein-70 and interleukin-15: prognostic biomarkers correlating with clinical severity and diagnostic efficacy in active alopecia areata
Abstract
Background Alopecia areata (AA) is an autoimmune disease that is characterized by transient hair loss without scarring. The lifetime risk of AA is ∼2%. It affects all skin and hair colors in both children and adults. Objective To evaluate the serum levels of heat shock protein-70 (HSP70) and interleukin-15 (IL-15) in individuals with AA and their relationship with disease severity. Patients and methods This case-control study included 120 participants: 60 patients (patients with AA), males only, and 60 controls, males. We assessed the serum levels of HSP70 and IL-15 in healthy controls and AA patients using enzyme-linked immunosorbent assay. All participants underwent clinical examinations and history-taking. Results Serum HSP70 (24.5±22.1 ng/ml vs. 10.3±4.6 ng/ml; P
Fields of Study & Subjects
Hair Growth and Disorders
Dyeing and Modifying Textile Fibers
Contact Dermatitis and Allergies
Publication details
- Journal / source
- Journal of the Egyptian Womenʼs Dermatologic Society
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Volume
- 23
- Issue
- 1
- Pages
- 37–43
- Publication date
- 1 January 2026
- Language
- EN