Factors Influencing Early Sputum Culture Conversion in Pulmonary Drug-resistant Tuberculosis
Abstract
Introduction: India bears the highest global burden of tuberculosis (TB), with multidrug-resistant TB (MDR-TB) posing substantial treatment challenges. Sputum culture conversion is a vital indicator of treatment response and an early predictor of success in drug-resistant TB (DR-TB). This study aimed to evaluate the time to early sputum culture conversion (within 6 months) in DR-TB patients and identify factors influencing this outcome across different resistance patterns: MDR, MDR with fluoroquinolone resistance, MDR with second-line injectable resistance, and extensively DR-TB (XDR-TB). Methods: This prospective cross-sectional observational study was conducted in India. Seventy-four DR-TB patients enrolled between January and October 2019 were assessed. Demographic data, comorbidities, and culture conversion times were analyzed using Chi-square tests and univariate logistic regression. P
Fields of Study & Subjects
Tuberculosis Research and Epidemiology
Diverse Scientific Research Studies
Healthcare Facilities Design and Sustainability
Publication details
- Journal / source
- Journal of Global Infectious Diseases
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Volume
- 18
- Issue
- 1
- Pages
- 27–34
- Publication date
- 1 January 2026
- Language
- EN