Correlation between H. pylori Infection and IL-8 and IL-17 in Chronic Gastric Patients in Iraq

Abstract Background: Several studies revealed that Helicobacter pylori can stimulate innate immunity by activating recurrent macrophages and neutrophils to initiate inflammation and also stimulate adaptive immunity mediated by the naïve T cell variation into Th 1, Th 17, and Th 2 immune cells. Objectives: This investigation examined the serum levels of two interleukins (IL-8 and IL-17) and the likely associations between them in H. pylori infection patients and healthy individuals at various stages. Materials and Methods: This study involved 145 participants, 80 of whom had H. pylori infection and 65 were healthy individuals. Serum levels of the ILs were measured using the enzyme-linked immunosorbent assay technique. The data were statistically analyzed to assess the socio-demographic characteristics and the correlation between ILs in both groups. Results: The results showed that women had more early-stage H. pylori infection diagnoses, while men had more advanced-stage cancer diagnoses. Younger people, men, and those with early H. pylori infection had higher levels of ILs. The levels of IL-8 and IL-17 were higher in the H. pylori infection groups. A strong correlation was found between IL-8 and IL-17 levels in both groups ( P = 0.0001). Conclusion: This study suggested that cytokine variation profiles could be useful for detecting H. pylori infection and predicting its outcome.