Predictors of Symptomatic Intracerebral Hemorrhage and Outcome in Acute Ischemic Stroke Postintravenous Thrombolysis

BACKGROUND AND OBJECTIVES: Limited data are available regarding symptomatic intracerebral hemorrhage (sICH) after intravenous thrombolysis (IVT) in acute ischemic stroke (AIS) from India. We analyzed the incidence, predictors, and functional outcome following sICH in the South Indian population. METHODS: We retrospectively analyzed all patients with AIS who were treated with IVT between January 2012 and December 2022. The potential predictors of sICH and functional outcome at 3 months were investigated using univariate and multivariate analysis. RESULTS: Of the 348 patients (71.55% men), 24 (6.92%) developed sICH. The patients with sICH had more severe stroke (National Institute of Health Stroke Scale [NIHSS] on admission 15.16 ± 5.07 versus 11.14 ± 5.48, P = 0.006), high blood glucose (BG) on admission (P = 0.001), high creatinine levels (P =