Development of an enhanced sensitivity method for lateral flow immunoassays: An overview of strategies

Tzu Chi Medical Journal 2026 Open access

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Authors: Chung-An Chen, Chi-Hung Liu, Natalie Yi‐Ju Ho, Sheng Liu, Tsung-Ting Tsai
DOI: 10.4103/tcmj.tcmj-d-25-00061
Cited by: 1
References: 93

Abstract

Lateral flow immunoassay (LFIA) is a widely recognized point-of-care diagnostic platform for detecting various analytes. It must meet the criteria of REASSURED, but poor sensitivity and lack of precision in test results remain the main bottlenecks of LFIA. Therefore, signal enhancement methods, such as devices, nanoprobes, or detection modes, can improve this platform. In this paper, many representative studies from the past decade on LFIA sensing platforms will be discussed in detail.

Fields of Study & Subjects

Biosensors and Analytical Detection Advanced biosensing and bioanalysis techniques Microfluidic and Bio-sensing Technologies

Publication details

Journal / source
Tzu Chi Medical Journal
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
38
Issue
1
Pages
11–20
Publication date
1 January 2026
Language
EN